Kezar Life Sciences to Host Conference Call and Webcast during the American College of Rheumatology Annual Meeting to Discuss Updated Results with KZR-616
To access the live conference call via phone, dial 877-407-9711 (U.S. toll-free) or 412-902-1014 (toll). The conference ID number for the live call is 13696599. Additionally, a live webcast of the call will be available under the Events section of the Company’s website at http://investors.kezarlifesciences.com/events. A slide presentation will accompany the call and can be accessed via the weblink. An archived replay of the call will be available at http://investors.kezarlifesciences.com/events for 90 days following the live call.
KZR-616 is a novel, first-in-class, selective immunoproteasome inhibitor with broad therapeutic potential across multiple autoimmune diseases. Pre-clinical research demonstrates that selective immunoproteasome inhibition results in a broad anti-inflammatory response in animal models of several autoimmune diseases, while avoiding immunosuppression. Phase 1b clinical trial results in patients with systemic lupus erythematosus provide early evidence that KZR-616 potentially avoids adverse effects caused by currently marketed non-selective proteasome inhibitors, which we believe prevent them from being utilized as a chronic treatment in autoimmune disorders. Phase 2 trials have commenced for the treatment of lupus nephritis (MISSION study), dermatomyositis and polymyositis (PRESIDIO study), and autoimmune hemolytic anemia and immune thrombocytopenia (MARINA study).
About the MISSION Study
The MISSION study (NCT03393013) is a Phase 1b/2 multi-center study designed to evaluate the safety, tolerability, and efficacy of KZR-616. The study consists of 2 parts. The Phase 1b portion is an open-label, multiple dose escalation study to evaluate the safety and tolerability of KZR-616 in patients with systemic lupus erythematosus, and the Phase 2 portion is a randomized, placebo-controlled, double-blind study to evaluate the safety and efficacy of three separate doses of KZR-616 in patients with active proliferative lupus nephritis.
Source: Kezar Life Sciences, Inc.